Main Street Inn

Vermillion, SD · Bed & breakfast

Rating
5.0/5
★★★★★ 5.0
Reviews
20
Rank in Vermillion
#1
of 5 hotels
City Percentile
100%
rating percentile
Address
Main Street Inn, 221 E Main St, Vermillion, SD 57069
Phone
(605) 464-1667
Website
www.mainstreetinnsd.com

Main Street Inn is a hotel located in Vermillion, SD. It is one of 5 hotels listed in Vermillion. Its 5.0-star rating is above the Vermillion city average of 4.2 stars. Based on combined rating and review volume, it currently ranks first among hotels in Vermillion. There are 10 photos associated with this location.

Customer Reviews

kenl203 · Dec 2025

Beyond expectations. It is a former fraternity house with an easy walk to the USD Campus. Incredibly restored, classy & tasteful touches and the pics online are authentic to how in looks in real time. Comfort level is high with plenty of hot water for showers, rooms that feel like home, refreshment centers on each floor, and a solid breakfast. But, the friendly & kind host makes the experience truly shine. A relaxing atmosphere that had me wanting to stay longer (rare for me); I do plan to return to this unique & ideal place. Thank you, Carson.

★★★★★ 5.0 Michelle Bjelland · Sep 2025

Just a quick overnight stay with a late arrival but couldn't be made to feel more at home. Beautifully restored home with specious bedroom including large bathroom with walk in shower. Very clean and comfortable. I wanted to steal one of there pillows 😉 Will definitely try to come back for a longer stay. Highly recommend!

CordeliaMinnesota · Oct 2025

First impression was welcoming. Beautiful Amish made furniture throughout. It was formally a fraternity house. Carson, the Innkeeper, was very pleasant and accommodating. Our room, #201 had 2 queen beds and a beautiful large bathroom with a walk in showers. We stayed 2 nights. The breakfasts were delicious with eggs, waffles, stuffed french toast,meat, fruit, juice, coffee. It is in a quiet residential area, close to downtown where there are restaurants. We would highly recommend this B&B.|There are no rooms on the main floor, therefore you do have to walk up the steps. |Carson was good to carry our bags up for us.

★★★★★ 5.0 Steve Nelson · Sep 2025

Can’t say enough good things about the Main St Inn. The room was great and an excellent location close to downtown. The family that runs it are absolutely lovely people - extremely friendly and make you feel like family yourself. And don’t get me started on the breakfast. If they are making stuffed French toast, you’re in for a treat. The only complaint I have is that there’s not about a hundred more rooms because I won’t stay anywhere else in Vermillion going forward and I’m sure anyone else that’s stayed there feels the same way! Thank you again!

lynettej943 · Aug 2025

This was the second time I've stayed at the Main Street Inn--both times were excellent, prompting me to write this review. The rooms are really spacious and decorated with a cool, comfortable, craftsman style. The comfort stations (with drinks and snacks) were a really nice touch. The breakfasts were yummy. All public spaces were clean. And the location can't be beat (an easy walk to the downtown area where there's a sweet little theater, coffee shop, and fun places to eat). I will be staying at the Main Street Inn every time I visit Vermillion--nothing else in town compares.

Accessibility & Amenities

✓ Lgbtq Friendly

Services

Bed & breakfast

Top Hotels in Vermillion

NameRatingReviews
Red Roof Inn Vermillion - U of South Dakota★★★★☆ 4.120 reviews
Prairie Inn★★★★☆ 3.520 reviews
Holiday Inn Express & Suites Vermillion by IHG★★★★☆ 4.00 reviews

This listing is informational. Contact the business directly to verify credentials, services, and availability.